Treatment Resistant Depression (TRD)

Many people who receive antidepressant treatment for their depression do not get an adequate response to the medicines they are taking. If someone is taking two or more antidepressants and they are failing, this is sometimes referred to as treatment-resistant depression or TRD. The COMP 005 study is looking into a new treatment approach for people with TRD using an investigational medicine given with psychological support. The study is suitable for people who have been diagnosed with major depression and are currently experiencing a recurrent or single episode of depression but that have not responded to antidepressant treatment.

You may be eligible to participate in a Compass Pathfinder study if you:

• Are 18 years of age or older
• Have been diagnosed with major depression (single or recurrent episodes)
• Are experiencing treatment-resistant depression, defined as failing 2, 3 or 4 pharmacological treatments for your current episode of depression
• Meet additional study criteria.